Solid dispersion as a formulation strategy: A mini review

  • Pravin Kumar Patel Nutra Med Packaging, 118 Algonquin parkway, Whipanny, New Jersey 07981
Keywords: solid dispersion, solubility, drug delivery systems, amorphous, crystalline, review


Oral route has been the most preferred route for administration of drug.  However, in recent years majority of new drug candidates exhibit poor aqueous solubility for oral administration and hence pose a challenge for the formulation scientist [1].   Dissolution and/or permeation across the gastrointestinal membrane are the rate limiting step for oral absorption of drugs.  Majority of the drugs belong to Class II of Biopharmaceutical Classification System (BCS).  For these drugs, dissolution is the sole rate limiting step in oral absorption [2]. The current review lightens the advantages of the solid dispersion and discusses the production techniques, types of solid dispersion, and methods to choose a suitable carrier. Also, the common characterization techniques are explained. This mini review would help the readers understand the overall concept of solid dispersion as a drug delivery system.


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How to Cite
Patel, P. (2017). Solid dispersion as a formulation strategy: A mini review. International Journal of Chemical and Life Sciences, 6(6), 2039-2045.
Review Article